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SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.4
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
Direct relationship to heart disease
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
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9
Vitamin D reduces foam cell formation
Vitamin D reduces VSMC foam cell formation and protects against AS progression.
Highly relevant to cardiovascular management
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
Highly relevant to cardiovascular disease.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
Most Useful Reviews
8
Strengthened bones
Great! This complex is beneficial at a promotional price. Calcium strengthens bones, cartilage, and joints. Magnesium helps the nervous system and regulates blood pressure. Zinc aids in collagen synthesis, essential for gut health, the immune system, and the reproductive system. This complex is useful for cardiovascular disease, memory issues, and muscle pain from heavy exercise. I take one tablet after dinner. Magnesium has also improved my sleep and alleviates night leg cramps.
Read More
8
Bone mineral density
Excellent! The quality is superb. Calcium is vital for strong bones and teeth, playing a key role in muscle control and blood circulation. Magnesium enhances bone growth and regulates blood pressure, while zinc supports protein production and wound healing. Vitamin D is crucial for calcium absorption and supports the immune system while regulating genes. It aids weight loss and is essential for a healthy pregnancy, supporting fetal immunity. This combination significantly helps with cardiovascular disease.
Read More
8
Improved cardiovascular health
The perfect combination! This combination is ideal: zinc aids bone formation, calcium maintains bone strength, and magnesium assists absorption in bone tissue. This complex benefits the cardiovascular system, lowering blood pressure and alleviating irritability. It enhances disease resistance and improves brain function. Additionally, vitamin D significantly enhances the effectiveness of other components, ensuring their proper absorption. I highly recommend this perfect combination of vitamins for cardiovascular disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.4
9
Vitamin D reduces foam cell formation
Vitamin D reduces VSMC foam cell formation and protects against AS progression.
Highly relevant to cardiovascular management
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
Highly relevant to cardiovascular disease.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
9
Zinc nanoparticles reduce heart damage
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Moderate relevance to cardiovascular research
We focused our research on how zinc oxide nanoparticles (ZnONPs) might help reduce heart damage caused by cisplatin, a well-known chemotherapy drug. In this study, we used rats divided into different groups, some receiving varying doses of ZnONPs and others serving as control groups.
Our findings indicated that as the dosage of ZnONPs increased up to 50 mg/kg, there was a marked improvement in cardiovascular markers. We observed reduced levels of oxidative stress, inflammation, and cell damage in the heart tissues of those treated with ZnONPs. More specifically, measures related to heart tissue health and serum biomarkers showed that rats receiving higher doses exhibited recovery similar to that of healthy rats.
Overall, we concluded that ZnONPs serve as a protective agent against cisplatin-induced cardiotoxicity, showcasing their potential in improving heart health during cancer treatment.
Our findings indicated that as the dosage of ZnONPs increased up to 50 mg/kg, there was a marked improvement in cardiovascular markers. We observed reduced levels of oxidative stress, inflammation, and cell damage in the heart tissues of those treated with ZnONPs. More specifically, measures related to heart tissue health and serum biomarkers showed that rats receiving higher doses exhibited recovery similar to that of healthy rats.
Overall, we concluded that ZnONPs serve as a protective agent against cisplatin-induced cardiotoxicity, showcasing their potential in improving heart health during cancer treatment.
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9
Zinc counters heart cell injury
Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.
Highly relevant to cardiovascular health
We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.
Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.
Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.
Read More
8
Vitamin D3's role in cardiovascular health
Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.
Explores vitamin D3's effects
Our study delved into the potential benefits of vitamin D3 in improving cardiovascular health, particularly among hypertensive patients suffering from obesity and obstructive sleep apnea (OSA). We designed a randomized clinical trial where participants received either dapagliflozin (an SGLT-2 inhibitor), vitamin D3, a combination of both, or no treatment over a period of 16 weeks.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
8.3
Bone tissue support
Nature's Bounty, Calcium Magnesium Zinc with Vitamin D3 is great for lowering osteoporosis risk and strengthening bones. Calcium and vitamin D3 work together effectively for bone health. Magnesium actively participates in bone growth, and zinc stimulates bone tissue formation. Additionally, both minerals offer numerous benefits for the immune, nervous, and cardiovascular systems. I find this complex invaluable for maintaining my bone and heart health.
Read More
8
Strengthened bones
Great! This complex is beneficial at a promotional price. Calcium strengthens bones, cartilage, and joints. Magnesium helps the nervous system and regulates blood pressure. Zinc aids in collagen synthesis, essential for gut health, the immune system, and the reproductive system. This complex is useful for cardiovascular disease, memory issues, and muscle pain from heavy exercise. I take one tablet after dinner. Magnesium has also improved my sleep and alleviates night leg cramps.
Read More
8
Bone mineral density
Excellent! The quality is superb. Calcium is vital for strong bones and teeth, playing a key role in muscle control and blood circulation. Magnesium enhances bone growth and regulates blood pressure, while zinc supports protein production and wound healing. Vitamin D is crucial for calcium absorption and supports the immune system while regulating genes. It aids weight loss and is essential for a healthy pregnancy, supporting fetal immunity. This combination significantly helps with cardiovascular disease.
Read More
8
Improved cardiovascular health
The perfect combination! This combination is ideal: zinc aids bone formation, calcium maintains bone strength, and magnesium assists absorption in bone tissue. This complex benefits the cardiovascular system, lowering blood pressure and alleviating irritability. It enhances disease resistance and improves brain function. Additionally, vitamin D significantly enhances the effectiveness of other components, ensuring their proper absorption. I highly recommend this perfect combination of vitamins for cardiovascular disease.
Read More
7.5
Accelerated recovery
The vitamin complex is wonderful! The concentration is just right, especially at this price. However, I encountered issues: the tablets are quite large, making them hard for children or teens to swallow, and I am allergic to them, despite needing these vitamins. Nevertheless, they assisted my dad’s recovery from coronavirus and eased its aftermath. So, I can recommend them, but do be cautious of your body's reactions, especially for cardiovascular disease.
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